Fatty Liver Disease: A Crosstalk Between Lipid Species

Fatty Liver Disease: A Crosstalk Between Lipid Species

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The role of different lipid species such as free fatty acids and sphingolipids in non-alcoholic fatty liver disease (NAFLD) has been extensively studied during the last decade.In addition, free cholesterol read more accumulation in hepatocytes plays a crucial role in the transition from steatosis to steatohepatitis.However, the contribution of these lipids to NAFLD pathology is often evaluated individually.This review attempts to enclose jeff rosenstock buffalo the main metabolic and signalling connections between lipotoxic lipid species, and how their homeostasis is disrupted in NAFLD.